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We utilize in vivo CRISPR methodology in mouse models of HNSCC and investigate oncological mechanisms that drive the HNSCC with the ultimate goal of developing novel drug targets to treat this deadly cancer. In collaboration with other faculty members in Head and Neck Surgery department, Cancer Research Program, RI-MUHC and Goodman Cancer Research Centre, we focuses on:

1) Establishing HNSCC mouse models of novel tumor suppressors

2) Investigating drug targets from GPCR superfamily using in vivo CRISPR screening in HNSCC mouse models and

3) Utilizing patient-derived xenograft models to study drug targets and oncological mechanisms in HNSCC