21) Gauthier MA, Kadam A, Leveque G, Golabi N, Zeitouni A, Richardson K, Mascarella M, Sadeghi N, Loganathan SK. Long-read sequencing of oropharyngeal squamous cell carcinoma tumors reveal diverse patterns of high-risk Human Papillomavirus integration
. Front. Oncol., 17 October 2023
. Volume 13.| https://doi.org/10.3389/fonc.2023.1264646
20) Yan Y, Gauthier MA, Malik A, Fotiadou I, Ostrovski M, Dervovic D, Ghadban L, Tsai R, Gish G, Loganathan SK*, Schramek D*. The NOTCH-RIPK4-IRF6-ELOVL4 Axis Suppresses Squamous Cell Carcinoma. Cancers (Basel). 2023 Jan 25;15(3):737. doi: 10.3390/cancers15030737. https://www.mdpi.com/2072-6694/15/3/737*Corresponding authors
19) Vujovic A, de Rooij L, Keyvani Chahi A, Chen HT, Yee BA, Loganathan SK, Liu L, Chan DCH, Tajik A, Tsao E, Moreira S, Joshi P, Xu J, Wong N, Balde Z, Jahangiri S, Zandi S, Aigner S, Dick JE, Minden MD, Schramek D, Yeo GW, Hope KJ. In vivo screening unveils pervasive RNA-binding protein dependencies in leukemic stem cells and identifies ELAVL1 as a therapeutic target. Blood Cancer Discov. 2023 Feb 10:BCD-22-0086. doi: 10.1158/2643-3230.BCD-22-0086.
18) Langille E, Al-Zahrani KN, Ma Z, Liang M, Uuskula-Reimand L, Espin R, Teng K, Malik A, Bergholtz H, El Ghamrasni S, Afiuni-Zadeh S, Tsai R, Alvi S, Elia A, Lu Y, Oh RH, Kozma KJ, Trcka D, Narimatsu M, Liu JC, Nguyen T, Barutcu S, Loganathan SK, Bremner R, Bader GD, Egan SE, Cescon DW, Sorlie T, Wrana JL, Jackson HW, Wilson MD, Witkiewicz AK, Knudsen ES, Pujana MA, Wahl GM, Schramek D. Loss of epigenetic regulation disrupts lineage integrity, induces aberrant alveogenesis and promotes breast cancer. Cancer Discov. 2022 Sep 15:CD-21-0865. doi: 10.1158/2159-8290.CD-21-0865
17) Yanchus C, Drucker KL, Kollmeyer TM, Tsai R, Winick-Ng W, Liang M, Malik A, Pawling J, De Lorenzo SB, Ali A, Decker PA, Kosel ML, Panda A, Al-Zahrani KN, Jiang L, Browning JWL, Lowden C, Geuenich M, Hernandez JJ, Gosio JT, Ahmed M, Loganathan SK, Berman J, Trcka D, Michealraj KA, Fortin J, Carson B, Hollingsworth EW, Jacinto S, Mazrooei P, Zhou L, Elia A, Lupien M, He HH, Murphy DJ, Wang L, Abyzov A, Dennis JW, Maass PG, Campbell K, Wilson MD, Lachance DH, Wrensch M, Wiencke J, Mak T, Pennacchio LA, Dickel DE, Visel A, Wrana J, Taylor MD, Zadeh G, Dirks P, Eckel-Passow JE, Attisano L, Pombo A, Ida CM, Kvon EZ, Jenkins RB, Schramek D. A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation.
Science. 2022 Oct 7;378(6615):68-78. doi: 10.1126/science.abj2890. Epub 2022 Oct 6.
16) Michmerhuizen NL, Heenan C, Wang J, Leonard E, Bellile E, Loganathan SK, Wong SY, Lei YL, Brenner JC. Combined Pik3ca-H1047R and loss-of-function Notch1 alleles decrease survival time in a 4-nitroquinoline N-oxide-driven head and neck squamous cell carcinoma model.
Oral Oncol. 2022 Mar;126:105770. doi: 10.1016/j.oraloncology.2022.105770
15)
Loganathan SK, Malik A, Langille E, Luxenburg C, Schramek D. In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity. J Vis Exp. 2020 Nov 2;(165). doi: 10.3791/61693.
14) Loganathan SK, Schleicher K, Malik AA, Quevedo R, Langille E, Teng K, Oh R, Rahtod B, Tsai R, Tehrani PS, Pugh TJ, Gingras AC & Schramek D (2020) Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling. Science, 367(6483):1264-1269. https://doi.org/10.1126/science.aax0902
13) Loganathan SK and Schramek D (2020) In vivo CRISPR screens reveal potent driver mutations in the long-tail of Head and Neck cancers. Molecular and Cellular Oncology, 13;7(4):1758541. doi: 10.1080/23723556.2020.1758541
12) Loganathan SK, Malik AA, Langille E, Chen L and Schramek D (2020) In vivo CRISPR
screening methodology to simultaneously evaluate gene function in mouse skin and oral cavity. J Vis Exp. 2;(165). doi: 10.3791/61693.
11) Malhotra D, Loganathan SK, Chiu AM, Lukowski CM & Casey JR (2019) Human corneal expression of SLC4A11, a Gene mutated in Corneal dystrophies. Scientific Reports, 9(1):9681
10) Loganathan SK, Schneider HP, Morgan PE, Deitmer JW, Casey JR. Functional assessment of SLC4A11, an integral membrane protein mutated in corneal dystrophies.
Am J Physiol Cell Physiol. 2016 Nov 1;311(5):C735-C748.
9) Chiu AM, Mandziuk JJ, Loganathan SK, Alka K, Casey JR. High Throughput Assay Identifies Glafenine as a Corrector for the Folding Defect in Corneal Dystrophy-Causing Mutants of SLC4A11. Invest Ophthalmol Vis Sci. 2015 Dec;56(13):7739-53.
8) Loganathan SK, Lukowski CM, Casey JR. The cytoplasmic domain is essential for transport function of the integral membrane transport protein SLC4A11. Am J Physiol Cell Physiol. 2016 Jan 15;310(2):C161-74.
7) (*Equal first author contribution) * Vilas GL, * Krishnan D, * Loganathan SK, Malhotra D, Liu L, Beggs MR, Gena P, Calamita G, Jung M, Zimmermann R, Tamma G, Casey JR, and Alexander R. Increased Water Flux Induced by an Aquaporin-1/Carbonic Anhydrase II interaction. Mol. Biol. Cell. 2015 Mar 15;26(6):1106-18.
6) Soumittra N, Loganathan SK, Madhavan D, Ramprasad VL, Arokiasamy T, Sumathi S, Karthiyayini T, Rachapalli SR, Kumaramanickavel G, Casey JR and Rajagopal R. Biosynthetic and functional defects in newly identified SLC4A11 mutants and absence of COL8A2 mutations in Fuchs endothelial corneal dystrophy. J Hum Genet. 2014 Aug;59(8):444-53.
5) Loganathan SK and Casey JR. Corneal Dystrophy-Causing SLC4A11 Mutants: Suitability for Folding-Correction Therapy. Hum Mutat. 2014 Sep;35(9):1082-91. (Article selected for a video highlight: http://www.youtube.com/watch?v=rLvUicNtsoM)
4) Bridgewater LC, Mayo JL, Evanson BG, Whitt ME, Dean SA, Yates JD, Holden DN, Schmidt AD, Fox CL, Dhunghel S, Steed KS, Adam MM, Nichols CA, Loganathan SK, Barrow JR and Hancock CR. A novel bone morphogenetic protein 2 mutant mouse, nBmp2NLS (tm), displays impaired intracellular Ca2+ handling in skeletal muscle. Biomed Res Int. 2013;2013:125492.
3) Vilas GL, Loganathan SK, Liu J, Riau AK, Young JD, Mehta JS, Vithana EN and Casey JR. Transmembrane water-flux through SLC4A11: a route defective in genetic corneal diseases. Hum Mol Genet. 2013 Nov 15;22(22):4579-90.
2) Vilas GL, Loganathan SK, Quon A, Sundaresan P, Vithana EN and Casey JR. Oligomerization of SLC4A11 protein and the severity of FECD and CHED2 corneal dystrophies caused by SLC4A11 mutations. Hum Mutat. 2012 Feb;33(2):419-28.
1) Vilas GL, Morgan PE, Loganathan SK, Quon A and Casey JR. A biochemical framework for SLC4A11, the plasma membrane protein defective in corneal dystrophies. Biochemistry. 2011 Mar 29;50(12):2157-69.